Senior Research Associate, Downstream Processing

Cirsium Biosciences is creating the next generation of manufacturing technologies for viral vector production. Our novel plant-based platform solves the existing problems of speed, ﬂexibility, scalability, and safety in viral vector manufacturing while dramatically reducing production costs. Our goal is to enable global and equitable access to life-changing genetic therapies.

Position Overview

Location: Onsite, San Diego

Job Type: Full-Time

We are seeking a highly skilled and motivated Senior Research Associate, Downstream Processing to join our dynamic team. The successful candidate will play a critical role in research projects, with a focus on the downstream processing part of AAV production using whole plants. The Senior Research Associate will work closely with the Downstream Processing Scientist and cross-functional teams to ensure the efficient and cost-effective production of high-quality products in compliance with regulatory standards.

This position requires an individual with a strong background in Chromatography, molecular biology and hands-on experience in purifying AAVs, proteins, or vaccines. The ideal candidate will have experience working in a GMP environment and be ready to start immediately and contribute to our innovative research initiatives.

Key responsibilities

Assist in the development and optimization of downstream processes for the purification of biologics, including chromatography, filtration, ultrafiltration/diafiltration (UF/DF), and viral clearance.

Design and execute experiments to evaluate and improve process performance, yield, and product quality.

Purify material for research purposes.

Assist in scaling up and transferring downstream processes from the laboratory to pilot and manufacturing scales, ensuring robustness and reproducibility.

Collaborate with upstream process development and manufacturing teams to integrate downstream processes into overall production workflows.

Perform process characterization and validation studies to support regulatory submissions and ensure compliance with current Good Manufacturing Practice (cGMP) guidelines.

Troubleshoot and resolve process-related issues during development, scale-up, and production.

Prepare technical reports, process descriptions, and Standard Operating Procedures (SOPs) to document process development activities.

Stay current with advancements in downstream processing technologies and apply best practices to enhance process efficiency and product quality.

Provide technical support to manufacturing teams during process implementation and commercial production.

Participate in cross-functional project teams and contribute to project planning, risk assessment, and decision-making processes.

Qualifications

M.S. or B.S. in Biochemistry, Chemical Engineering, Biotechnology, or a related field, with 3+ years (M.S.) or 5+ years (B.S.) of relevant experience in downstream process development in the biopharmaceutical industry.

Hands-on experience with biologics downstream processing techniques such as chromatography (affinity, ion exchange, size exclusion), filtration (depth filtration, tangential flow filtration), and UF/DF.

Experience with DSP in AAV is a plus.

Familiarity with process scale-up, technology transfer, and cGMP requirements.

Strong problem-solving skills and the ability to troubleshoot complex process issues.

Proficiency in data analysis, process optimization, and statistical tools (e.g., Design of Experiments).

Knowledge of regulatory guidelines and quality control procedures in a research environment is preferred.

Strong analytical and problem-solving skills, with attention to detail.

Excellent communication and interpersonal skills.

Ability to work independently and as part of a collaborative team.

CIRSIUM EMPLOYEE BENEFITS

Cirsium Employee Benefits

Competitive Salary

Stock Options

Generous PTO

Professional Development Opportunities

Health Insurance & Health Savings Account

401(k) Plan

Dental Insurance

Life & AD&D Insurance

Vision Insurance

Employee Assistance Program (EAP)

And More...

Cirsium Biosciences is an emerging company located in San Diego, California. We offer highly competitive compensation and employee programs, including comprehensive health, dental and vision plans, generous time off, and equity in our early-stage company. We are dedicated to fostering a workplace that keeps our team inspired and engaged. We offer an inclusive company culture where employees feel respected and valued.

Cirsium Biosciences is proud to be an equal opportunity employer. All qualiﬁed applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation, veteran status, or any other protected categories.

PLEASE EMAIL YOUR RESUME TO CAREERS@CIRSIUMBIO.COM TO APPLY.